Tuesday, January 12, 2010

Breakthrough in Gene Therapy for Ankylosing Spondylitis

The BBC new reported on Monday, Januray 11th, that two genes have been identified by a consortium of scientist from Oxford University (England), the University of Queensland (Australia), and the University of Texas that have a strong connection to Ankylosing Spondylitis, better known as AS.

The disease can result in a person becoming fixed in a bent position looking down at their feet. The identification of these two genes (ERAP1 and IL23R) could help in developing a modality of treatment for this condition.

Currently treatment involves pain killers and physiotherapy although some patients are treated with costly antibodies. The study found six regions of the genome that were associated with AS. ERAP1 is thought to control inflammation while IL23R has been implicated in psoriasis and inflammatory bowel disease.

There are many theories as to what causes AS but understanding which genes involved could lead to a new treatment. Gene Therapy, the future of spine? Kudos to those scientist that labor behind the curtain hoping to make real advancements in spine care that will make a difference.


  1. Here is a link to more information about the genetics of Ankylosing Spondylitis that was prepared by our genetic counselor and which has links to some useful resources for those dealing with this condition: http://www.accessdna.com/condition/Ankylosing_Spondylitis/41. There is also a phone number listed if you need to speak to a genetic counselor by phone. I hope it helps. Thanks, AccessDNA

  2. People living with Ankylosing Spondylitis or AS spend huge money for therapy sessions and painkillers. With the discovery of the genes that are associated with AS, scientists in the future could unlock the key to treating AS in an affordable way.

  3. one of my relatives has also been diagnosed with AS - he has undergone several medications but the pains recurs - can you pl let us know what all medications did your brother go through?

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